CENTER FOR APPLIED MATHEMATICS AND THEORETICAL PHYSICS
UNIVERZA V MARIBORU UNIVERSITY OF MARIBOR
KREKOVA 2 SI-2000 MARIBOR SLOVENIA
Phone +(386) (2) 2355 350 and 2355 351 $\bullet$ Fax +(386) (2) 2355 360
Robnik@uni-mb.si $\bullet$ www.camtp.uni-mb.si
PROF.DR. MARKO ROBNIK, DIRECTOR

Seminarsko predavanje
Centra za uporabno matematiko in teoreticno fiziko

Modeling the human cardiovascular-respiratory control system: an optimal control application to orthostatic stress

Dr. Jerry Batzel
SFB "Optimization and Control"
Karl-Franzens-Universität, Graz, Austria

Abstract: We describe a model of the human cardiovascular-respiratory control system. We will approach the modeling of the control system by viewing it as an optimal control problem. Many physiologists consider optimization as a basic influence in the evolution of biological systems (Kenner 1979). We adapt a model given in Timischl 1998 which has been previously used to study congestive heart failure $[1]$. Sudden change in position (supine to standing) results in change in physical stress (orthostatic stress) on the cardiovascular system. System response to orthostatic stress has been extensively studied $[2]$ but a number of issues are not well understood. The model is adapted using extra compartments and control loops to study the control of blood pressure and the avoidance of hypotension and those factors that influence cardiovascular adaptation to orthostatic stress. The goal is to provide insight into such conditions as orthostatic intolerance. Simulations are compared to data. References: $[1]$ J. J. Batzel et al Technical Report 191 SFB F-003 Bericht, Karl-Franzens-Universität, 2000; $[2]$ T. Heldt et al, J. Appl. Physiol. 92(3), pp. 1239-1254, 2002.

Seminarsko predavanje bo v torek 20. maja 2003 ob 15:15 uri v seminarski sobi CAMTP, Krekova 2, pritlicje desno. Vljudno vabljeni vsi zainteresirani, tudi študentje.

Prof.Dr. Marko Robnik
-- Direktor CAMTP --